Role of B Cells in Rheumatic Autoimmune Disease
نویسندگان
چکیده
There is increasing evidence that B cells can play important roles in the pathogenesis of various autoimmune diseases, either by autoantibody secretion, production of proinflammatory cytokines or autoantigen presentation. An increasing number of B cell directed therapies are in development as a possible treatment strategy of rheumatic autoimmune diseases, such as Rituximab which targets the B cell specific CD20 surface marker. This article provides an overview of the principal understandings of B cell immunology in autoimmunity and selected rheumatic autoimmune diseases. Keyword: B cells, Rheumatic autoimmune disease, Autoantibody, Cytokine, B cell depletion, Rituximab
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